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KMID : 0381319800190010001
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Korean Journal of Occupational Health
1980 Volume.19 No. 1 p.1 ~ p.6
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The Relationship Between Urine Volume and Urinary Excretion of Lead, ALA and Coproporphyrin
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이세훈/Lee, Se Hoon
김정만/이병국/이광묵/Kim, Chung Man/Lee, Byung Kook/Lee, Kwang Mook
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Abstract
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In order to study the effect of urine volume on the alteration of urinary excretion of lead, ALA and coproporphyrin of thirty Korean albino rabbits in accordance with the intensity of the lead intoxication, authors calculated the Spearman´s rank correlation between seventy-two hours urine volume and the other parameters.
Thrity rabbits were divided equally into two groups of fifteen rabbits each. Lead acetate was injected subcutaneously six times a week for six weeks with total amount of 1.8 milligrams per killogram of bodyweight for group Ⅰ, and 18 milligrams per kilogram of bodyweight for group Ⅱ.
The results were as follows:
1. The urinary excretion of lead was significantly correlated with the urine volume in all experimental groups (F＜0.05－0.001). And also, the Spearman´s rank correlation was lowered in accordance with increment of urinary excretion of lead.
2. All groups but group Ⅱ, the urinary excretion of ALA was significantly correlated with the urine volume (P＜0.01－0.001).
3. In all groups, urinary excretion of coproporphyrin was significantly correlated with the urine volume (P＜0.05－0.01).
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